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P46 A Recombinant 63-kilodalton Form of Bacillus anthracis Protective Antigen Produced in the Yeast Saccharomyces cerevisiae Provides Protection in Two Inhalational Challenge Models of Anthrax Infection. R. W. Hepler1, R. Kelly1, T. B. McNeely1, H. Fan1, M. C. Losada1, H. A. George1, A. Woods1, L. D. Cope1, A. Bansal1, J. C. Cook1, G. Zang1, S. L. Cohen1, X. Wei1, P. M. Keller1, E. K. Leffel2, J. G. Joyce1, M. L. M. Pitt2, L. D. Schultz1, K. U. Jansen1, M. Kurtz1 1Merck Research Labs, West Point, PA, 2US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD. P47 A Recombinant Leishmania Antigen Related to the Silent Information Regulatory 2 SIR2 ; Protein Family Induces a B cell Activation and Antibody Specific Immune Response R. Silvestre1, A. Cordeiro-da-Silva1, A. Ouaissi2 1Faculdade Farmcia and I.B.M.C. of Universidade Porto, Porto, PORTUGAL, 2Institut de Recherche pour le Dveloppement, UR008, Montpellier, FRANCE. P48 DNA Vaccine Expressing D8L of Vaccinia Virus Enhanced the Efficacy of Multi-gene Smallpox DNA Vaccine Formulations P. V. Sakhatskyy, S. Wang, T. Chou, S. Lu University of Massachusetts Medical School, Worcester, MA. Abstract We compared the weight-reducing effect of diet and gastroplasty with that of diet alone in a randomized trial in 60 morbidly obese patients followed for two years. Initial median body weight was 120 kg in patients randomly assigned to gastroplasty plus diet and 115 kg in those assigned to diet alone. Maximum weight losses did not differ significantly between the groups 26.1 kg in the gastroplasty group and 22.0 kg in the group treated with diet alone, P 0.05 ; . The risk of a Type II error with a true difference larger than 9.5 kg was less than 5 per cent. However, the group treated with diet alone regained significantly more weight after maximum weight loss had been achieved, so that the gastroplasty group had a more favorable net outcome at two years P 0.05 ; . The positive and negative effects of gastric surgery for obesity have not been evaluated prospectively in patient groups randomly assigned to either gastroplasty or a nonsurgical dietetic regimen. We undertook such a study because the justification of surgery for obesity depends on its risks and advantages, as compared with those of the most effective nonsurgical alternative. Patients and methods All 128 patients with morbid obesity who were admitted to the obesity clinic at Hvidovre Hospital between September 1979 and May 1981 were evaluated consecutively according to the study protocol. Three patients were excluded because they were less than 60 per cent overweight, as indicated by a Scandinavian standard, 1 and 47 were excluded for the following reasons: age less than 18 or more than 54 years 14 patients ; , no treatment previously attempted 3 ; , treatment contraindicated because of chronic bronchitis 1 ; , abuse of alcohol or drugs 6 ; , other ongoing treatment for obesity 2 ; , and unwillingness to cooperate or occupational or geographic factors impeding participation 21 ; . Of the 78 patients eligible for enrollment, 11 refused surgical treatment and 3 refused nonsurgical treatment. Four patients dropped out before assignment to a treatment group. The final study group consisted of 60 patients. Following the instructions for random assignment made beforehand by a third party, we assigned the patients in equal numbers to gastroplasty or to a very-low-calorie diet. After random assignment to gastroplasty, two patients refused the operation, and in one it could not be performed because of hepatomegaly caused by fatty infiltration. The gastroplasty group consisted of 24 women and 3 men with a median age of 35 years range, 21 to 53 ; and a median body weight of 120 kg range, 94 to 166 ; , corresponding to a median excess weight of 82 per cent range, 61 to 160 ; . The patients assigned to a very-lowcalorie diet included 26 women and 4 men with a median age of 33 years range, 18 to 53 ; and a median body weight of 115 kg range, 98 to 206 kg ; , corresponding to a median excess weight of 87 per cent range, 68 to 174 ; . Gastroplasty was performed according to the approach described by Gomez.2 In all but the first three patients the staple line was secured by a row of silk sutures on the anterior and.

This article presents the results of a systematic survey of studies in any language, published before August 2000, on the use of cannabinoids to control emesis in patients undergoing emetogenic chemotherapy. The study was conducted in response to growing demand among members of the British medical profession that marijuana Cannabis sativa ; be re-legalized as a prescription drug, in a return to its pre-1971 status. The authors found 30 randomized studies, in which a total of 1, 366 patients were involved, comparing cannabis with placebo or with conventional antiemetics that met their search criteria. Medications tested in these studies included oral nabilone a synthetic cannabis component ; , oral dronabinol 9tetrahydrocannabinol, one of the main active ingredients in cannabis ; , and injectable levonantradol. No marijuana was smoked in any of the studies. Conventional antiemetics used in the studies surveyed included prochlorperaizne, metoclopramide, chlorpromazine, thiethylperazine, haloperidol, domperidone, and alizapride. No comparison of cannabinoids with a serotonin 5-HT ; receptor antagonist, which the authors believe would provide the best comparator for prevention of acute emesis in highly emetogenic chemotherapy, was found. The article includes detailed information on how the search for relevant studies was conducted, how studies were evaluated for selection, how data from selected studies was extracted, and how the data was analyzed. Characteristics of the studies selected are shown in Table 1. The authors found that cannabinoids were more effective than conventional antiemetics and placebos, especially in trials where the emesis event rate was between 25% and 75%. Where milder emetogenic drugs were used, there was little difference between cannabinoids and conventional antiemetics. Where harsher chemotherapy drugs were used, cannabinoids were not very effective. No conclusions could be.

Olney, Richard F Olsen, Steven C, PT 118, 203, 212 Olsen, Steven M, MD 291 Olshansky, Brian, MD 215 Olson, Brett J, MD Olson, Charles E 317 Olson, Charles M, MD 122 Olson, Christina K, PT 229, 282 Olson, Daniel R 334 Olson, David L 325 Olson, Jennifer M, DO Olson, John H, PA . 126, 156, 189, Olson, John K, MD Olson, Joy L, MD Olson, Leatrice A, DO 182 Olson, Loren A, MD 98, 101 Olson, Michael M 113 Olson, Ole J, DC 124 Olson, Paul J, MD 197 Olson, Richard J, MD Olson, Timothy P, MD 101 Olwan, Dena Z, PhD . 110 Omaha Ambulatory Surgery . 312 Omaha Medical Supplies . 335 Omaha Surgical Center Ltd 312 Omar, Majdi A, MD Omar, Mark D 325 Omeara, Michael J, OD 74, 80, 85 Omega Surgery Centers . 312 Omojola, Matthew F 346 On With Life At Glenwood . 202 On With Life Inc . 126 Oneal, Elaine A, LISW 95-96, 106 Oneil, Michael T, MD 152 Ong, Paulette J, PA 173 Onishi, Marla J, MD Onsrud, Rachel L, ARNP . 183 Onuigbo, Anthony A, MD Opdebeeck, Kathleen E, MD Opheim, Kent R, MD Oppert, David C, MD 193 Option Care Enterprises, Inc 335 Option Home Health . 142 Oral, Resmiye, MD . Orange City Health System . 257 Orange City Hospital And Clinic . 3, 257 Oren, Ron M, MD 208, 216 Orewiler, Wilda L, PA 281 Organ, Mirian B, MD Orosz, Michael A, DPM . 147 Ortega, Deems F, PhD . 101 Ortell, Edward B, DO 259 Orthosource, Inc. - Dme . 308 Orthotek Inc Dme . 179 Ortiz Biachi, Ada I, MD Ortiz Bianchi, Ada I, MD 48, 50, 52 Ortiz, Publio O, MD Ortman, Shirley K 329 Orton, Dale W . 321 Orton, Donald F 346 Orvis, Bradley R, MD 176, 256 Osadsky, Rastislav, MD . 23, 41 Osaro, Oduah D, MD Osborn, Steven M Osbourne, Kathryn . 349, 355 Osceola Comm Health Srvs . 269 Osceola Community Hospital . Osceola Nrc . 258 Osmundson, Gregory D, MD Ossian Seniorhospice . 259 Ostbloom, Norman D, LISW .95-96, 106 Ostdiek, Donald P 307, 339 Osten, Joel J 319 Osterhaus Pharmacy Incdme . 242 Osterhaus, Julie K, ARNP . 222 Osterholm, O. D 346 Osterholm, Richard . 325 Osterkamp, Teri L, ARNP 208, 234 Ostrander, Jamie W, OD 74, 80, 82, Osullivan, Cormac T, CRNA 224 Oswald, Kristine F, LISW and duragesic.

BY ROBERT E. PIERRE Washington Post For years, universities have been licensing federally funded research to private companies that turn the abstract knowledge into such familiar products as Gatorade and Citracal. This college town, home of Kansas State University, is no different, with several would-be millionaires with ties to the university toiling away in cubicles and laboratories just off campus, hoping to turn their research into profitable businesses. But here in the "Little Apple, " as the city calls itself, there is a new twist to this old idea. In addition to using the knowledge created by its own staff and students, the university, through a nonprofit firm set up for that purpose, goes scavenging at companies large and small, looking for patents that aren't being used and asking for the right to try to do something with them. They've hit a gold mine. R.J. Reynolds Tobacco Co. donated million in machinery and patents. Cleveland Industrial giant Eaton Corp. gave 57 patents, estimated at million, in areas including anti-lock braking systems and laser-based semiconductor manufacturing. Procter & Gamble Co. donated the patent rights for a technology that allows a fruity mixture of juice and milk, a type of smoothie, to remain stable and not turn into clabber. All the donations were made to the Mid-America Commercialization Corp., a nonprofit firm that tries to turn the university's intellectual property into profits. The companies receive a tax break for the donation -- and good publicity, sometimes -- but they must relinquish all rights to the donated patents. The university, in turn, gains access to expensive research that could turn into a profitable product. If things go really well, the university might sell the newly formed company back to the original company or another well-financed buyer. It's unclear whether all the donations will pan out, but the Procter & Gamble donation is starting to pay off. NutriJoy Inc., a for-profit spin-off of the nonprofit group, recently launched a new juice and milk drink called Cal-C that is a big seller in grocery stores here and in a test market in California, where the product is made. With various flavors, the drink's selling point is that a 20-ounce bottle has a full day's supply of Vitamin C and 50 percent more calcium than milk. The feat was made possible by the patent donation, plus lots of tinkering at the university. "We're positioning it as a juice drink, " said David Yang, who heads NutriJoy Inc., founded in June 2000 by the nonprofit group and the Kansas State Research Foundation. "But the benefits are more towards the dairy products." 27 and efalizumab.

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