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One extreme were enthusiasts for electronic preprints, who regard them not as scientific papers in evolution but as near enough finished articles. To these respondents, the current long process of peer review and paper publication is detrimental to science and the public health: any way of getting scientific advances into the public domain fast is worth supporting. Some welcomed the opportunity to obtain comments from a much wider pool than traditional peer review allowed for and to have authors address these comments before formal publication. However, the Medical Journal of Australia's experiment of posting accepted papers on its website and inviting comments from visitors does not suggest that there exists a large pool of qualified referees prepared to provide detailed, high quality reviews of papers on line C Bingham, personal communication ; . ; At the other extreme were respondents who thought "too much junk" was already being published. Lacking the skills to distinguish between "valuable material and garbage" journalists and the public could be misled. Where the conclusions of research might change public health policy, medical practice, or patients' lifestyles then full peer review before publication should be the rule. The circulation of preprints should be restricted to those who can properly judge them. Might there be a middle way? Analogous to the preprint is the conference presentation or abstract, which airs research before it has been formally "written up" and peer reviewed. The International Committee of Medical Journal Editors Vancouver group ; has decided that policies designed to limit prepublication publicity should not apply to these forms of early communication.4 Perhaps this exception should be extended to electronic preprints, providing they were clearly labelled as such. A warning along the lines of, "Electronic preprint. This research has not yet been accepted for publication by a peer reviewed journal: please do not quote" might sound the right tone. In the words of John Ziman, physicist and philosopher of science, "It must always be clear. We are grateful to A.-G. Myrann and J. Jacobsen for expert technical assistance, and to T.-G. Iversen for critical comments on the manuscript. This work was supported by the Norwegian Cancer Society, The Norwegian Research Council for Science, the Humanities and the Jahre Foundation and Jeanette and Sren Bothners legacy.
MAJOR 2005MAJOR PROGRAMMES SCHEMES 2005-06 Construction of 140 Type II and 32 Type III staff quarters at Kalyanwas was started after dismantling of existing 121 Type I staff quarters under Phase II of the Scheme. Construction of 82 Type I and 76 Type II staff quarters at Dwarka could not be completed due to some dispute with contractor. Construction of 36 Type V and 16 Type VI staff quarters for Delhi Government Officers started at Vasant Kunj. Repair and renovation works carried out in the existing Delhi Government staff quarters. Any new Night Shelter could not be constructed by Slum Wing during the year.

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We report the case of a 49-year-old woman who developed an endobronchial mycotic pulmonary artery aneurysm PAA ; as a complication of pneumonia. After presenting with patchy infiltrates, she developed right lung atelectasis. A noncontrast chest CT scan revealed a mass in the right hilum, and bronchoscopy identified an obstructing lesion in the right mainstem bronchus. Unfortunately, biopsy caused massive hemorrhage, and the patient died. An autopsy identified a mycotic PAA that had invaded the right mainstem. The case suggests that a contrasted CT scan should be included in the evaluation of endobronchial masses and that PAA should be included in the differential diagnosis of such lesions. CHEST 2003; 124: 1610 CONTRAINDICAT1ONS Nordil is conrraindicared in patients with known sensitivity to the drug. pheochromocyromo. congestive heart failure, a history of liver disease, or abnormal liver function tests. See WARNINGS for other conditions. ; The porenriarion of sympatt'iomimeric substances by MAO inhibitors may result in hypertensive crises See WAlNINGS ; : therefore, patients taking Nardil should nor be given sympothomimetic drugs including methyl dopa. L-dopa, dopamine. and trypromine-conraining substances as well as epinepl'irine and norepinephrine ; : or foods with a high concentration of rrypromine-conroining substances or tyromlne pods of brood beans, aged cheeses, beer. wines. pickled herring. yogurt. liver. yeast extract ; . Excessive amounts of caffeine and chocolate con also cause hypertensive reactions. hard ; should not be used in combination with some CNS depressants such as alcohol and narcotics e.g meperidine ; : death has been reporte# tn patients i who have received meperidine and Nardil concomitantly. Nardil should nor be odminisrered together with or in ropid succession to other MAO inhibitors because HYPERTENSIVE CRISES and convulsive seizures, fever, marked swearing. excitation, delirium. tremor, coma, and circulatory cotlapse may occur. List of MAO InhIbItors GenerIc Name Trodemork pargyline hydrochloride Euronyl' Abbort Laboratories ; porgyline hydrochloride Eurronx Abborr and methyclothiazide Laboratories ; furazoiidone Furoxone Eaton Laboratories ; isocarboxazid Marplon' Roche ; procarbazine Marulanex Roche ; rranylcypromine Parnate' Smith Kline & French Laboratories ; tktienrs taking Nardil should not undergo elective surgery requiring general anesthesia. Also they should not be given cocaine or local anesthesia containing symparho. mimetic vosoconstrictors. The possible combined hyporensive effects of Nardil and spinal anesthesia should be kept in mind. Nordil should be discontinued at least 10 days prior to elective surgery. IMPORTANT Womingslhe most serious reactions to Nardil involve changes in blood pressure. HypertensIve CrIses: The most important reaction associared with Nardil administration is the occurrence of hypertensive crises. which have sometimes been fatal. These crises are characterized by some or all of the following symptoms: occipital headache which may radiate frontally, palpitarion. neck sriffness or soreness, nausea, vomiting. swearing sometimes with fever and sometimes with cold, clammy skin ; , dilated pupils. and photophobia. Either rachycardia or bradycardia may be present and can be associated with constricting chest pain. NOTE: Intracranial bleeding has been reported in associanon with the increase in blood pressure. should be observed frequently to detect of any pressor response in all patients receiving Nardil Therapy should be discontinued immediately upon the occurrence of palpirarion or frequent headaches during therapy and procrit.

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As survival rates for young cancer patients continue to improve, protection against iatrogenic infertility caused by chemotherapy with or without radiotherapy assumes higher priority. Hodgkin's disease is the most common malignancy in the population aged 1524 years. Prolonged survival of almost 90% of patients is now expected for young patients treated with cytotoxic chemotherapy for Hodgkin's disease. This is due to the introduction of effective chemotherapy such as MOPP mechlorethamine, vincristine, prednisone and procarbazine ; and or ABVD adriamycin, bleomycin, vinblastine and decarbazine ; and its variants. Similar rates of long-term survival have been reported for patients with non-Hodgkin lymphoma, as well as for patients with other types of tumours receiving chemotherapy Blumenfeld et al., 1999 ; . It was estimated that by the year 2010 one in 250 of the young adult population would be a long-term survivor of childhood cancer Wallace, 1997 ; . Moreover, cytotoxic agents have been also used as chemotherapy for various autoimmune diseases such as systemic lupus erythematosus SLE ; , rheumatoid arthritis, and for the prevention of organ transplant rejection Blumenfeld et al., 1999 ; . Females are generally less susceptible than males to the deleterious effects of chemotherapy on the gonad. Nevertheless, ovarian dysfunction is well-recognized following combination chemotherapy. Treatment of Hodgkin's disease with mechlorethamine, vinblastine, procarbazine and prednisolone MVPP ; , or MOPP results in ovarian failure in 19-63%. Amenorrhoea is much more commonly encountered in women over 30 years than in younger women where ovarian function appears to be preserved in 48-100% Mackie et al., 1996 ; . Long-term follow-up will be necessary as a number of these young women may subsequently progress to a premature menopause Thomson et al., 2002 ; . The major challenge faced by pediatric oncologists today is to sustain the excellent survival rates while striving to achieve optimal quality of life. One of the most frequently encountered and psychologically traumatic late complications of radiotherapy and chemotherapy for childhood cancer is infertility. Consequently.

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1st dam SHAM BASTY, by Sham. Winner at 2, , 933. Dam of 3 foals of racing age, including a 2-year-old of 2005, two to race, one winner-Baileys Jet g. by Mister Baileys-GB ; . Winner at 3, , 654. 2nd dam * BASTY, by Bobby. 6 wins, 2 to 4 in Argentina, Premio Club Hipico de Santiago de Chile, Premio Bonzo, Premio Tespia, Premio Venezuela, Premio Jockey Club de San Pablo, 2nd Premio Helda, Premio Black Beauty, Premio Arturo A. Bullrich, Premio Paulina, Premio Clemente Benavides, 3rd Premio Monserga, Premio Chile, Premio Nogoya, Premio Caballerizas Argentinas, Premio Jockey Club de Peru, Premio Trisca, Premio Cote d'Or; 11 wins, 5 to 7, , 285 in N.A. Dam of 5 other foals to race, all winners-Bold Playmate c. by Bold Play ; . 2 wins, 3rd Louisiana Futurity Males-R. True Basty. Winner at 2, , 313. Chadra. Winner at 3, , 826. Dam of 7 winners-Chadra North f. by Far North ; . 8 wins, 2 to 4, , 988, 2nd Lorelei S. LAD, , 000 ; , 3rd Red Camelia H. [R] FG, , 478 ; . Dam of Silver Chadra g. by Silver Deputy ; 10 wins, 4, 525, 2nd Jefferson Cup S. []L], CD, , 100, 3rd Lecomte H. [L], FG, , 000. Bold Chadra g. by Bold Play ; . 4 wins, 2 to 4, , 558, 2nd Louisiana Futurity [R] FG, , 511 ; , Minstrel S. LAD, , 116 ; , Stardust S. [R] LAD, , 920 ; . Chad's Play. 5 wins, 2 to 5, , 639. Hell's Fury. 3 wins at 3 and 5, , 754. Beau Basty. 8 wins at 3 and 4, , 008. Producer. Partez Lady. 5 wins, 2 to 6, , 497. Chadra's Prince. 4 wins, 2 to 5, , 011. Nasty Basty. 4 wins, 2 to 5. Pacific Basty. Winner at 2, , 005. Playful Basty. Unraced. Dam of-Basty Bag'n. Winner at 2, , 005. 3rd dam BAYANITA, by Baxar. Unraced. In Argentina. Dam of- * BASTY. Black type winner, see above. Accredited Texas-bred.

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BRIEF REPORTS TABLE 1. Demographic and Clinical Characteristics of Patients With Moderately Refractory Schizophrenia Randomly Assigned to Treatment With Risperidone or Clozapine, by Treatment Group and Trial Completion Status Variable Risperidone N 50 ; % 82 Treatment Group Clozapine N 47 ; % 76 Trial Completion Status Discontinued Trial N 62 ; N % Mean Age years ; Spatial working memory performance 5-second delay Baseline 29 weeks 15-second delay Baseline 29 weeks Baseline psychotic symptoms Baseline negative symptoms 41.9 SD 9.2 Range 2163 Mean 41.9 SD 8.1 Range 2258 Mean 41.0 79 21 Completed Trial N 35 ; N % Mean 43.3 80 20 and protopic.
Curred exclusively in diabetic animals and was not observed in normoglycemic animals treated with CsA. However, both the incidence and severity of atherosclerotic lesions were significantly greater in allograft than isograft diabetic animals. 2 ; Fructose feeding had no impact on fasting glucose levels, but mildly raised total cholesterol, triglyceride, and insulin levels. Fructose feeding in the absence of diabetes did not alter the incidence of TxCAD but in the presence of diabetes showed a trend toward decreased severity of TxCAD. 3 ; Graft survival was significantly decreased in diabetic allografts compared with nondiabetic allografts and isografts; this difference was associated with a higher incidence and severity of TxCAD in the diabetic allografts. 4 ; Native hearts of diabetic transplant recipients showed no vascular disease. Our first observation suggests that diabetes plays a significant role in the development of TxCAD. Specifically, diabetes augments and accelerates development of TxCAD in allograft animals. Furthermore, it appears to trigger development of mild TxCAD even in isografts. These observations suggest a relative order of importance for the effects of diabetes, alloimmunity, and vascular injury in accelerating the course of TxCAD in this model. That is, since the severity of TxCAD in diabetic allografts diabetic isografts nondiabetic allografts no TxCAD ; , this sequence suggests that of the three factors mentioned, diabetes has the most profound effect on the development of TxCAD. Moreover, alloimmuTABLE 4. Correlation of Metabolic Abnormalities With Transplant Coronary Artery Disease TxCAD and procarbazine.

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The basic concept of dual-stream approach is to design a bi-continuous product with an aqueous continuous phase containing mild surfactants for cleansing and a separate oil continuous phase containing petrolatum for active skin moisturization Figure 1 ; . This new approach offers significant advantages over the conventional emulsion-based 2-in-1 cleansers due to minimized surface area of contact between the surfactant phase and the lipid phase. Therefore, it allows us, for the first time, to be able to break the performance-deposition tradeoffs often seen in the conventional body wash systems caused by strong negative interaction between surfactant and lipid. The fundamental science behind the dual-stream formulation is quite fascinating. The aqueous surfactant phase contains highly concentrated multi-lamellar vesicles 80% in aqueous phase volume ; which are self-assemblies of amphiphilic surfactants as revealed by cryo-TEM image Figure 2 ; . Formation of these surfactant self-assemblies and its phase behavior play a crucial role in the dual-stream product design and its superior performance and protriptyline. APPENDIX I INT 0143 RTOG 93-10 SWOG 9310 AN INTERGROUP PHASE II COMBINED MODALITY TREATMENT OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA Sample Patient Consent Form RESEARCH STUDY I have the right to know about the procedures that are used in my participation in clinical research so as to afford me an opportunity to make the decision whether or not to undergo the procedure after knowing the risks and hazards involved. This disclosure is not meant to frighten or alarm me; it is simply an effort to make me better informed so I may give or withhold my consent to participate in clinical research. PURPOSE OF THE STUDY It has been explained to me that I have lymphoma of the brain. My doctor feels that my participation in this study may be helpful. The purpose of this study is to determine whether chemotherapy in addition to radiotherapy is a beneficial treatment for primary central nervous system lymphoma. Primary lymphoma of the brain is a rare tumor which is usually treated with whole-brain radiotherapy. In most patients, radiation causes substantial shrinkage or disappearance of the tumor; however, in the vast majority of patients, the tumor comes back. Chemotherapy combined with radiation has been used successfully in the treatment of identical lymphomas which occur in other areas of the body outside of the brain. For this reason, I have been asked to join a study using both chemotherapy and brain radiation for the treatment of lymphomas restricted to the brain. Pregnant or nursing patients are excluded from participation. Sexually active male and female patients must avoid pregnancy during therapy. DESCRIPTION OF PROCEDURES 10 1 96 ; The treatment to be given to me is follows: I will be examined by a physician involved in this study and have several tests before treatment begins including a spinal tap and an examination by the ophthalmologist eye doctor ; . In addition, I will have a blood test to check for exposure to HIV, the virus which causes AIDS since primary nervous system lymphoma may be associated with AIDS which would change my treatment. Unless done during the brain biopsy procedure, a reservoir for the administration of chemotherapy into my spinal fluid must be inserted; this is called an Ommaya reservoir. The Ommaya reservoir is a small plastic device under the skin on my head, about the size of a quarter, which allows for easy sampling and delivery of drug into the spinal fluid; it is inserted under local or general anesthesia by my neurosurgeon. It is permanent although it can be removed if necessary. Most of the chemotherapy will be given before brain radiation begins and will require four days of hospitalization for each dose of chemotherapy. Three different drugs will be used before the radiation begins. One drug, Methotrexate, will be given by vein 2 hr intravenous infusion ; and also into my spinal fluid by repeated 5 ; taps of the Ommaya reservoir. Vincristine will be given by vein administration takes a few minutes ; and procarbazine will be given by mouth. Dexamethasone will be given orally for the first six weeks during chemotherapy and may again be given during radiation. The full course of chemotherapy will take about 10 weeks to complete, and my blood counts will be closely followed during this time. Brain radiation will begin after the chemotherapy; I will have a CT or scan and eye examination after chemotherapy and before radiation is started. If tumor is still present on this CT or MR scan, or an eye examination I will receive radiation treatments once a day every day, Monday through Friday. If eye examination shows tumor in my eye s ; , radiation will also be given to my eye s ; . The course of radiation will take about five weeks to complete. If no tumor is visible on this CT or MR scan, I will receive radiation treatments twice a day, 6 hours apart, every day, Monday through Friday. This course of radiation will take three.

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